Background: Ethics is one of the most important principles in knowledge commercialization, thus considering this factor is necessary for the higher education system. Accordingly, this study aims at analyzing ethical factors in knowledge commercialization. 
Method: The research was conducted based on content analysis and inductive approach. Based on knowledge commercialization the number of 60 English and Persian articles with the same subject were selected from 2006 up to now published in research and science standard journals. In order to identify the factors, Nvivo software was used. In face validity and reliability parts, the Holesti method was used for the reliability of extracted theme and the descriptive and interpretive face validity was used for the validity part.
Results: Researcher identified 54 effective factors by revising the literature review and asking authorities` idea. These factors categorized into 3 main dimensions. Then, in the next step the relationship between dimensions and ethical indices of knowledge commercialization was determined and analyzed consistently. Ethical factors of knowledge commercialization are 3 widespread themes in higher education include substructures with 2 organizer theme of justice and responsibility and the education widespread theme, with 2 organizer themes of learning-teaching process, and culturalizing and the support widespread theme include 2 organizer themes of commercial and social support.
Conclusion: The widespread and organizer themes of ethical factors of knowledge commercialization in higher education can be an appropriate model for policymaking, recording a plan of changing the knowledge to the wealth and using its application in research centers and universities