Background: Health Care workers, especially nurses, because of deal with patients, mortality and other sources of stress, are prone to burnout. In order to identify factors affecting the reduction of burnout, this study examined the relationships between Ethical Leadership, Spirituality at Work, and Burnout among Nurses at Government hospitals in Sanandaj.

Methods: The method of this research is descriptive - correlative. Statistical population included all Nurses in public hospitals (410 people) that, 148 subjects were selected using random sampling. Data gathering tools were three questionnaires: Ethical Leadership Questionnaire, Spirituality at Work Questionnaire and Burnout Questionnaire. Data analysis was performed by Structural Equation Modeling.

Results: Results showed that Ethical Leadership and Spirituality at Work have correlation with Burnout. Results also showed that Spirituality at Work plays a mediatory role in increasing the relationship between ethical leadership and burnout.

Conclusion: Based on the findings, particular attentions to ethical values ​​by managers and organizational leaders have felt. So it is necessary to implement those practices ethically and spirituality in concern.